Effect of TNF-Gold Nanoparticles Combination on Kidney and Liver Parameters of Female Mice

Background: Nanomedicine has emerged as a powerful platform for applying nanotechnology in the prevention and treating many diseases. Objective: To investigate toxicity of designated anti-cancer drugs composed gold nanoparticles (GNPs), tumor necrosis factor-alpha (TNF-α), cysteine-Alanine-Leucine-Asparagine-Asparagine (CALNN) peptide on kidney liver parameters, using animals’ model. Methods: A Combination TNF-α CALNN surface GNPs were achieved depending formation dative covalent bond between molecules pH solutions, which leads to react with active groups different nanoparticles, characterized ultraviolet visible spectroscopy. Moreover, their effects blood variables had been examined. These values included measurement glutamic oxaloacetic transaminase, pyruvic transaminase alkaline phosphatase, creatinine, urea levels after intraperitoneal injection an drug female albino mice. Results: Overall, results indicated that there was no significant change concentration biochemical treated control groups. Conclusion: The suggest GNPs-TNF-α-CALNN combination have harmful impact organs tested Keywords: Nanomedicine, GNPs, TNF-α, peptide, delivery, cytotoxicity Citation: Abood NA, Kadhim HS, Jabir MS. Effect TNF-gold parameters Iraqi JMS. 2022; 20(2): 245-251. doi: 10.22578/IJMS.20.2.12